Sodium Hydroxide → HCID 2726590, compound

HRID 1461469Notes

Reaction equation

HRID 1461469 reaction equation
Cl.[C:2]([NH2:7])(=[NH:6])[CH:3]([CH3:5])[CH3:4].[CH3:8][O:9][C:10](OC)=[N:11][C:12]#[N:13].[OH-].[Na+]>>[NH2:13][C:12]1[N:7]=[C:2]([CH:3]([CH3:5])[CH3:4])[N:6]=[C:10]([O:9][CH3:8])[N:11]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 90604Carbonimidic acid, N-cyano-, dimethyl esterHCID 27820532-Methylpropanimidamide hydrochloride

Product 1

HCID 2726590HCID 2726590, compoundYield 61.2%

Procedure

Cool the isobutyramidine hydrochloride solution in an ice bath. Charge 8 gm. (0.07 mole) dimethyl (N-cyanoimido)carbonate to the solution, followed by 5.8 gm. (0.073 mole) 50% NaOH, added dropwise. Stir while letting the mixture warm to room temperature for one hour. Remove the methanol by vacuum stripping, and slurry the resulting solids in75 ml. water. Cool and filter. Upon drying, 7.2 gm. (61.2%) 2-amino-4-isopropyl-6-methoxy-s-triazine is obtained, mp 116°-117° C.

Workup

  1. additionCharge 8 gm
  2. customRemove the methanol by vacuum stripping
  3. temperatureCool
  4. filtrationfilter
  5. customUpon drying

Sources & evidence

ORD record
ord-4181888b800d496bbffd01603f5c3803
Source dataset
uspto-grants-1991_12
Patent number
US05075443

Reaction notes

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