HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dichlorobenzaldehyde → HCID 15035858, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dichlorobenzaldehyde | HCID 35745 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Reactant | tert-Butyl 6-oxo-1,4-thiazepane-4-carboxylate 1,1-dioxide | HCID 19980844 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 15035858 | HCID 15035858 | — |
Reaction Steps
A mixture of 4-N-(t-butyloxycarbonyl)-1,1-dioxo -2,3,4,5,6,7-hexahydro-1,4-thiazepin-6-one (2.00 g, 7.60 mmole) from Example 6, 2,3-dichlorobenzaldehyde (1.33 g, 7.60 mmole) and ethyl 3-aminocrotonate (0.98 g, 7.60 mmole) was heated to reflux in 40 mL of ethanol for 24 hours. The ethanol was removed under reduced pressure and replaced with 85 mL of toluene. The mixture was heated to reflux for 2 hours, cooled to room temperature and filtered to obtain the produce (2.45 g, 61%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05075440 |
| Source dataset | uspto-grants-1991_12 |
| ORD ID | ord-06de9772ec26415da65775a0f59258d3 |
| Source note | uspto-grants-1991_12 |