HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (5-Methyl-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-3-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Nicotinoyl chloride | HCID 82604 | — |
| Reactant | 5-methyl-4,5-dihydro-1H-pyrazole | HCID 549780 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (5-Methyl-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-3-yl)methanone | HCID 3078468 | — |
Reaction Steps
Hydrochloride of nicotinic acid chloride (4 g) was suspended in 20 ml of chloroform followed by addition of a mixture of 1.7 g of 5-methyl-2-pyrazoline and 4 g of triethylamine, washing with water and concentration. The product was purified by chromatography on a silica gel column (chloroform/methanol=100/1). Yield; 3.4 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05075449 |
| Source dataset | uspto-grants-1991_12 |
| ORD ID | ord-5615206474d841d69cade3b6d5e6fd52 |
| Source note | uspto-grants-1991_12 |