Dicyclohexylcarbodiimide → HCID 19980018, compound

Participants

Reaction Steps

A mixture of 5.3 g of p-[p-(4-cyano-4-octylcyclohexyl)-phenyl]phenol (obtainable by alkaline ether splitting from r-1-cyano-cis-4-(4'-propyloxybiphenyl-4-yl)-1-octylcyclohexane with potassium tert-butylate in NMP at 180°), 1.9 g of optically active 2-chloro-3-methylbutyric acid and 170 g of DMAP are suspended in 40 ml of CH2Cl2. 3.1 g of DCC in 5 ml of CH2Cl2 are then added dropwise at 0° and stirring is carried out for 12 hours at room temperature. After separating off the dicyclohexylurea and the usual working up, optically active 4'-(4-cyano-4-octylcyclohexyl)-biphenyl-4-yl 2-chloro-3-methylbutyrate is obtained, K 81 SA 138 I.

Provenance & Evidence