Ammonia → HCID 14743548, compound

HRID 1461533Notes

Reaction equation

HRID 1461533 reaction equation
[O:1]1[CH:7]2[CH:2]1[C:3]([CH3:14])([CH3:13])[O:4][C:5]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][C:6]=12.[NH3:15]>C(O)C>[NH2:15][C@@H:7]1[C:6]2[CH:8]=[C:9]([CH3:12])[CH:10]=[CH:11][C:5]=2[O:4][C:3]([CH3:14])([CH3:13])[C@H:2]1[OH:1]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 13222997HCID 13222997, compound

Product 1

HCID 14743548HCID 14743548, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3,4-epoxy-3,4-dihydro-2,2,6-trimethyl-2H-1-benzopyran (7 g, see J. Med. Chem. 26, 1582, 1983) in concentrated ammonia solution (90 ml) and ethanol (160 ml) was stirred at room temperature for 5 days. Evaporation of solvent gave the title compound (7 g) as a crude solid which was used directly, without purification.

Workup

  1. customEvaporation of solvent

Sources & evidence

ORD record
ord-74e722ce1d13482ca7381f8d4051f7bc
Source dataset
uspto-grants-1991_12
Patent number
US05075460

Reaction notes

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