Zinc → Zn Desferal

HRID 1461555Notes

Reaction equation

[Zn:1].[CH3:2][C:3]([N:5]([OH:40])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]([CH2:14][CH2:15][C:16]([N:18]([OH:39])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:25]([CH2:27][CH2:28][C:29]([N:31]([OH:38])[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][NH2:37])=[O:30])=[O:26])=[O:17])=[O:13])=[O:4].[CH3:41][S:42]([OH:45])(=[O:44])=[O:43]>>[Zn:1].[CH3:2][C:3]([N:5]([OH:40])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]([CH2:14][CH2:15][C:16]([N:18]([OH:39])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:25]([CH2:27][CH2:28][C:29]([N:31]([OH:38])[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][NH2:37])=[O:30])=[O:26])=[O:17])=[O:13])=[O:4].[CH3:41][S:42]([OH:45])(=[O:44])=[O:43]

Participants

Reactant 2

HCID 23994Zinc

HCID 62881Deferoxamine Mesylate

Product 1

HCID 86745316Zn Desferal

Procedure

10 mM solution of Desferal (Ciba-Geigy, Basle) is mixed with an equal volume of 10 mM solution of ZnCl2 (A. R. Aldrich Chemical Co., Inc.) solution, titrated to pH 7.4. The mixture is heated for 30 min. to 45° C., and cooled and the complex Zn/Desferrioxamine B is formed. The ratio Zn:Desferal is 1.0:1.0.

Sources & evidence

ORD record: ord-7ea4e626b473424585e12aca659f18cf
Source dataset: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05075469

Reaction notes

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