Zinc → Zn Desferal

HRID 1461557Notes

Reaction equation

[Zn:1].[CH3:2][C:3]([N:5]([OH:40])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]([CH2:14][CH2:15][C:16]([N:18]([OH:39])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:25]([CH2:27][CH2:28][C:29]([N:31]([OH:38])[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][NH2:37])=[O:30])=[O:26])=[O:17])=[O:13])=[O:4].[CH3:41][S:42]([OH:45])(=[O:44])=[O:43]>>[Zn:1].[CH3:2][C:3]([N:5]([OH:40])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]([CH2:14][CH2:15][C:16]([N:18]([OH:39])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:25]([CH2:27][CH2:28][C:29]([N:31]([OH:38])[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][NH2:37])=[O:30])=[O:26])=[O:17])=[O:13])=[O:4].[CH3:41][S:42]([OH:45])(=[O:44])=[O:43]

Participants

Reactant 2

HCID 23994Zinc

HCID 62881Deferoxamine Mesylate

Product 1

HCID 86745316Zn Desferal

Procedure

10 mM solution of Desferal (Ciba-Geigy, Basle) is mixed with an equal volume of 12.5 mM of ZnCl2 (A. R. Aldrich Chemical Co., Inc.) solution, with 10 ml of 5.5 mM Histidine, titrated to pH 7.4. The mixture is heated for 30 min. to 45° C., and cooled and the complex Zn/Desferrioxamine B is formed, the ratio Zn:Desferal is 1.25:1.0

Sources & evidence

ORD record: ord-577c19da801a4e1380fa2602b9d83cc6
Source dataset: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05075469

Reaction notes

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