HRID1461557

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID23994

Zinc

结构：CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.CS(=O)(=O)O

HCID62881

Deferoxamine mesylate

C26H52N6O11S

PRODUCTS

生成物

结构：CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.CS(=O)(=O)O.[Zn]

HCID86745316

未命名化合物

PROCEDURE

实验过程

10 mM solution of Desferal (Ciba-Geigy, Basle) is mixed with an equal volume of 12.5 mM of ZnCl2 (A. R. Aldrich Chemical Co., Inc.) solution, with 10 ml of 5.5 mM Histidine, titrated to pH 7.4. The mixture is heated for 30 min. to 45° C., and cooled and the complex Zn/Desferrioxamine B is formed, the ratio Zn:Desferal is 1.25:1.0

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-577c19da801a4e1380fa2602b9d83cc6
来源数据集: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05075469
来源说明: uspto-grants-1991_12

反应 SMILES

[Zn:1].[CH3:2][C:3]([N:5]([OH:40])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]([CH2:14][CH2:15][C:16]([N:18]([OH:39])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:25]([CH2:27][CH2:28][C:29]([N:31]([OH:38])[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][NH2:37])=[O:30])=[O:26])=[O:17])=[O:13])=[O:4].[CH3:41][S:42]([OH:45])(=[O:44])=[O:43]>>[Zn:1].[CH3:2][C:3]([N:5]([OH:40])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]([CH2:14][CH2:15][C:16]([N:18]([OH:39])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:25]([CH2:27][CH2:28][C:29]([N:31]([OH:38])[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][NH2:37])=[O:30])=[O:26])=[O:17])=[O:13])=[O:4].[CH3:41][S:42]([OH:45])(=[O:44])=[O:43]