Zinc Sulfate → Zn Desferal

HRID 1461558Notes

Reaction equation

[CH3:1][C:2]([N:4]([OH:39])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11]([CH2:13][CH2:14][C:15]([N:17]([OH:38])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][NH:23][C:24]([CH2:26][CH2:27][C:28]([N:30]([OH:37])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][NH2:36])=[O:29])=[O:25])=[O:16])=[O:12])=[O:3].[CH3:40][S:41]([OH:44])(=[O:43])=[O:42].[O-]S([O-])(=O)=O.[Zn+2:50]>>[Zn:50].[CH3:1][C:2]([N:4]([OH:39])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11]([CH2:13][CH2:14][C:15]([N:17]([OH:38])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][NH:23][C:24]([CH2:26][CH2:27][C:28]([N:30]([OH:37])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][NH2:36])=[O:29])=[O:25])=[O:16])=[O:12])=[O:3].[CH3:40][S:41]([OH:44])(=[O:43])=[O:42]

Participants

Reactant 2

HCID 24424Zinc Sulfate

HCID 62881Deferoxamine Mesylate

Product 1

HCID 86745316Zn Desferal

Procedure

50 mM solution of Desferal (Desferrioxamine B) is mixed with 1/5 the volume of 50 mM solution of ZnSO4 (zinc sulfate heptahydrate, Aldrich Chemical Co., Inc.). The mixture is heated to for 45 min. to 40° C. and cooled to form the resultant Zn/Desferrioxamine (5 nM) complex. The ratio Zn/Desferal is 0.2:1.0

Workup

temperatureThe mixture is heated to for 45 min. to 40° C.
temperaturecooled

Sources & evidence

ORD record: ord-27d17bb382d24d12bc859c4a6ddea98f
Source dataset: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05075469

Reaction notes

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