反应详情

A mixture of 2-cycloheptenylamine (1.01 g), succinic anhydride (1.0 g) and acetic acid (10 ml) was heated under reflux for 24 hours. After cooling, ether (20 ml) was added to the reaction mixture which was then washed with a saturated aqueous sodium hydrogencarbonate solution, water and a saturated aqueous sodium chloride solution in this order. The organic layer was dried over anhydrous magnesium sulfate and concentrated. The oily product thus obtained was purified by column chromatography on silica gel to obtain 1.07 g of N-(2-cycloheptenyl)succinimide [[Compound (214)].

1. temperaturewas heated
2. temperatureunder reflux for 24 hours
3. temperatureAfter cooling
4. washwas then washed with a saturated aqueous sodium hydrogencarbonate solution, water
5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
6. concentrationconcentrated
7. customThe oily product thus obtained
8. customwas purified by column chromatography on silica gel