反应详情

To a solution of Phe-Leu-OMe (0.69 mmol) in CH2Cl2 (1 mL) was added dimethyl propylene oxide (0.075 mL). The reaction mixture was stirred at room temperature overnight, however, no change was observed. Two additional mLs of the oxide were added and then the reaction mixture was transferred with EtOH (excess) to a closed tube reactor, heated to 100° C. for 5 hours, stirred at room temperature for 2 days, and concentrated to yield 0.24 g of N-(2-hydroxy-2-methylpropyl)-L-phenylalanyl-L-leucine methyl ester.

1. temperatureheated to 100° C. for 5 hours
2. stirringstirred at room temperature for 2 days
3. concentrationconcentrated