Potassium Hydroxide → HCID 15754307, compound

Participants

Reaction Steps

0.5 g (0.008 mol) of potassium hydroxide powder was added to an ethyl alcohol solution of 8.2 g (0.02 mol) of N-(3,5-dichloro-4-methoxy-α,α-dimethylbenzyl)-N-(2-oxopropyl)phenylacetamide prepared by the method of Reference Example 8, and the mixture was refluxed under heating for 20 minutes. The reaction solution was cooled, and then ethanol was distilled off under reduced pressure. Water was added to the residue and extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure, followed by purification by silica gel column chromatography to obtain 5.2 g (yield: 66%) of the desired compound as colorless crystals.

Provenance & Evidence