Acetic Anhydride → HCID 19978925, compound

HRID 1461672Notes

Reaction equation

HRID 1461672 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([CH3:16])([CH3:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:4](=[O:17])[CH:3]1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[C:24](OC(=O)C)(=[O:26])[CH3:25]>N1C=CC=CC=1>[C:24]([O:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([CH3:16])([CH3:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:4](=[O:17])[CH:3]1[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)(=[O:26])[CH3:25]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 19978935HCID 19978935, compound

Product 1

HCID 19978925HCID 19978925, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3.6 g (0.0117 mol) of 4-hydroxy-1-(α,α-dimethylbenzyl)-3-phenyl-2-piperidone prepared by the method of Reference Example 19 and 10 ml of acetic anhydride were dissolved in 20 ml of pyridine, and the mixture was stirred at room temperature for one day and night. After completion of the reaction, the reaction solution was poured into ice water, extracted with ethyl acetate, washed with water and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 4.1 g (quantitatively) of the desired compound.

Workup

  1. customAfter completion of the reaction
  2. extractionextracted with ethyl acetate
  3. washwashed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-a8df6b773b3a450596ea67a86b735b3f
Source dataset
uspto-grants-1991_12
Patent number
US05076834

Reaction notes

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