1,2-Dimethoxyethane → N-((1,1-Dimethylethoxy)carbonyl)-L-valyl-L-proline methyl ester

Participants

Reaction Steps

In one practice of the present invention, triethylamine and diethyl phosphorocyanidate ("DEPC") are added to S-proline methyl ester and N-t-Boc-L-valine in 1,2-dimethoxyethane at 0° C. After holding for one hour at 0° C., the mixture is allowed to warm to room temperature ("RT") over 4 hours and diluted with ethyl acetate. The diluted mixture is then washed with 5% HCl followed by sodium hydrogen carbonate followed with saturated brine. The solvent is then removed by vacuum (in vacuo) to yield N-t-Boc-L-Val-L-Pro-OMe as a colorless syrup.

Provenance & Evidence