反应详情

N-Iodosuccinimide (2.75 g) was added to a stirred suspension of 4-trifluoromethylpyrimidin-6-one (1 g) in dry acetonitrile (13 ml). The reaction mixture was stirred at the ambient temperature for 2 hours, and then heated under reflux for 10 hours. After cooling, removal of the solvent under reduced pressure gave a brown solid which was recrystallised from water to give 5-iodo-4-trifluoromethylpyrimidin-6-one as a pale orange solid (150 mg);

1. temperatureheated
2. temperatureunder reflux for 10 hours
3. temperatureAfter cooling
4. customremoval of the solvent under reduced pressure
5. customgave a brown solid which
6. customwas recrystallised from water