Ethyl cyanoacetate → HCID 19979312, compound

Participants

Reaction Steps

The compound of formula III, when n and p are equal to 1 and q is equal to 1, is prepared from ethyl cyanoacetate and 2-chloro-4-fluoroacetophenone. The ethyl 2-(4-fluorophenacyl)cyanoacetate thereby obtained is then reacted with anhydrous ethylene glycol to obtain 2-[2-(2-cyanoethoxycarbonyl) ethyl]-2-(4-fluorophenyl)-l,3-dioxolane. Hydrogenation of the latter compound leads to 2-[2-(2-aminomethylethoxycarbonyl)ethyl]-2-(4-fluorophenyl)- 1,3-dioxolane, which is reacted with methylmagnesium iodide to obtain 2 (4-fluorophenyl)-2-[(2-oxo-azetidin-3-yl) methyl]dioxolane. This compound is subjected to the action of lithium aluminum hydride to obtain the expected compound.

Provenance & Evidence