1(2H)-Phthalazinone → HCID 19979310, compound

HRID 1461746Notes

Reaction equation

HRID 1461746 reaction equation
[OH-].[K+].[O:3]=[C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[N:6][NH:5]1.Br[CH2:15][CH2:16][O:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][O:19]1>O.CS(C)=O>[O:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH:18]1[O:17][CH2:16][CH2:15][N:5]1[N:6]=[CH:7][C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:4]1=[O:3]

Participants

6

Reactant 3

HCID 83941(2H)-PhthalazinoneHCID 14797Potassium HydroxideHCID 866212-(2-Bromoethoxy)tetrahydro-2H-pyran

Product 1

HCID 19979310HCID 19979310, compound

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Procedure

A solution of 41.5 g of potassium hydroxide in 53 ml of water is added at room temperature to a solution of 61 g of 1-oxophthalazine in 430 ml of dimethyl sulfoxide. After 30 minutes, 130 g of tetrahydro-2-pyranyl 2-bromoethyl ether are added to the suspension obtained. The mixture is left stirring for 30 hours at room temperature and then concentrated, the residue is taken up in 400 ml of water and the product is extracted with dichloromethane. The organic phase is concentrated.

Workup

  1. customobtained
  2. waitThe mixture is left
  3. concentrationconcentrated
  4. extractionthe product is extracted with dichloromethane
  5. concentrationThe organic phase is concentrated

Sources & evidence

ORD record
ord-725db703735c4a669a505d486e532aa0
Source dataset
uspto-grants-1991_12
Patent number
US05077288

Reaction notes

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