Ethyl cyanoacetate → HCID 19979312, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 86.7 g of sodium in 4,500 ml of anhydrous ethanol is added at 15° C. to a solution of 528 g of ethyl cyanoacetate in 500 ml of anhydrous ethanol. After one hour, the mixture is cooled to 0° C. and a solution of 620 g of 2-chloro-4-fluoroacetophenone in one liter of ethanol is added to the solution obtained. The reaction mixture is left for 12 hours at room temperature, then hydrolyzed with 200 ml of water and concentrated. The residue is taken up in one liter of water and this aqueous phase is neutralized to pH 7 and extracted with dichloromethane, followed by concentration.

Provenance & Evidence