HCID 19979379, compound → HCID 19979371, compound

Participants

Reaction Steps

11.9 g of 2,4-diisopropyl-6-(4-chlorophenoxy)-3-nitropyridine are dissolved in 120 ml of tetrahydrofuran and, after the addition of 12 g of Raney nickel (suspended in ethanol), hydrogenated under normal pressure at from +30° C. to +35° C. The reaction mixture is filtered over diatomaceous earth and the filtrate is concentrated. The residue is purified by column chromatography on silica gel (eluant: ethyl acetate/hexane 1:3). 2,4-Diisopropyl-6-(4-chlorophenoxy)-3-aminopyridine is obtained in the form of a light-yellow crystalline powder, m.p. 86°-88° C.

Provenance & Evidence