Benzoyl chloride → HCID 836063, compound

HRID 1461793Notes

Reaction equation

HRID 1461793 reaction equation
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:10][C:11]1[C:12]([Cl:17])=[N:13][CH:14]=[CH:15][CH:16]=1>N1C=CC=CC=1>[C:1]([NH:10][C:11]1[C:12]([Cl:17])=[N:13][CH:14]=[CH:15][CH:16]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 805282-Chloro-3-pyridylamine

Product 1

HCID 836063HCID 836063, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent2×

Conditions

Temperature
-5 °C

Procedure

3.9 g (28 mmol) of benzoyl chloride are added to 30 ml of pyridine while the temperature is maintained at approximately -5° C. A solution containing 3 g (23.3 mmol) of 3-amino-2-chloropyridine in 20 ml of pyridine is added to this solution using a pressure equalizing funnel. The reaction medium is left stirring overnight and then poured into a water/ice mixture. The solid obtained is then filtered off, washed several times with water and thereafter recrystallized in absolute ethanol.

Workup

  1. additionis added to this solution
  2. waitThe reaction medium is left
  3. customThe solid obtained
  4. filtrationis then filtered off
  5. washwashed several times with water
  6. customrecrystallized in absolute ethanol

Sources & evidence

ORD record
ord-edfbe51d03e64aa29e26919fd610f99c
Source dataset
uspto-grants-1991_12
Patent number
US05077408

Reaction notes

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