Phenethylamine → N-(2-phenylethyl)acetamide

Participants

Reaction Conditions

Reaction Steps

121.18 g of phenethylamine is dissolved in 450 ml of toluene in a 2 l three-necked flask. 102.09 g (95 ml) of acetic anhydride is added dropwise over a half hour period the temperature rises to 110° . After the addition is completed, the reaction solution temperature is maintained at approximately 95° C. The solvent is removed in vacuo and the residual oil was distilled under high vacuum (bp 160°-165° C./1mm) to afford 156.6 g of a white crystalline solid. The product exhibited NMR peaks (CDCl3, δ) at 7.35, 3.45, 2.80, and 1.90.

Provenance & Evidence