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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 14618Generated: October 25, 2026

3,4-Dichlorophenol → Rac-4-[2-(3,4-dichloro-phenoxy)-2-fluoro-acetylamino]-thiophene-3-carboxylic acid

https://huagongshe.com/reaction/14618

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-DichlorophenolHCID 7258—
Reactant4-(2-Chloro-2-fluoro-acetylamino)-thiophene-3-carboxylic acid methyl esterHCID 68689462—
ProductRac-4-[2-(3,4-dichloro-phenoxy)-2-fluoro-acetylamino]-thiophene-3-carboxylic acidHCID 16068688—

Reaction Steps

In analogy to Example 58, the title compound was prepared using 4-(2-chloro-2-fluoro-acetylamino)-thiophene-3-carboxylic acid methyl ester and 3,4-dichlorophenol. MS (m/e): 362.0 (M−H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07732452B2
Source datasetuspto-grants-2010_06
ORD IDord-2052f34460534cc1876edc3ac9e2e20d
Source noteuspto-grants-2010_06