Tributyl phosphite → Dibutyl P-[1-(N-Octadecyl-N-butoxyamino)octadecyl]phosphonate

Participants

Reaction Conditions

Reaction Steps

Following the procedure of Example 7, the title compound is prepared from 10.0 g (18 mmol) of N-(1-octadecylidene)octadecylamine N-oxide, 7.0 g (28 mmol) of tri-n-butyl phosphite and 5.15 g (28 mmol) of n-butyl iodide by heating at 70° C. for 16 hours. The residue is purified by flash chromatography (10:1 hexane:ethyl acetate eluent) followed by HPLC to give 4.9 g (35% yield) of the title compound as a white solid melting at 38°-40° C.

Provenance & Evidence