HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorodifluoroacetyl chloride → Rac-4-[2,2-difluoro-2-(4'-fluoro-biphenyl-4-yloxy)-acetylamino]-thiophene-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorodifluoroacetyl chloride | HCID 67713 | — |
| Reactant | 4-Fluoro-4'-hydroxybiphenyl | HCID 345420 | — |
| Reactant | Methyl 4-aminothiophene-3-carboxylate | HCID 2777610 | — |
| Product | Rac-4-[2,2-difluoro-2-(4'-fluoro-biphenyl-4-yloxy)-acetylamino]-thiophene-3-carboxylic acid | HCID 16068689 | — |
Reaction Steps
In analogy to Example 58, the title compound was prepared using 4-amino-thiophene-3-carboxylic acid methyl ester, chlorodifluoroacetyl chloride and 4-fluoro-4′-hydroxybiphenyl. MS (m/e): 406.1 (M−H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732452B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-97d98d3be3ea433fbff47711219bf1d3 |
| Source note | uspto-grants-2010_06 |