反应详情

A mixture of 40.5 g of 3-(tetradecyloxy)benzeneacetic acid, methyl ester, 18.8 g of potassium hydroxide, 15 ml of water and 300 ml of ethyl alcohol is refluxed for 4 hours. The solvent is removed and the residue partitioned between chloroform and dilute hydrochloric acid. The organic layer is dried and evaporated to a residue which is crystallized from carbon tetrachloride:hexane to give 31.8 g of the desired product as a white solid.

1. temperatureis refluxed for 4 hours
2. customThe solvent is removed
3. customthe residue partitioned between chloroform and dilute hydrochloric acid
4. customThe organic layer is dried
5. customevaporated to a residue which
6. customis crystallized from carbon tetrachloride