HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 3-Methyl-2-[[3-[acetyl[2-[4-(tetradecyloxy)phenyl]ethyl]amino]phenyl]methyl]thiazolium iodide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | HCID 15030169 | HCID 15030169 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Methyl-2-[[3-[acetyl[2-[4-(tetradecyloxy)phenyl]ethyl]amino]phenyl]methyl]thiazolium iodide | HCID 15030156 | — |
Reaction Conditions
| Temperature | 140 °C |
|---|
Reaction Steps
A mixture of 300 mg of N-[2-[4-(tetradecyloxy)phenyl]ethyl]-N-[3-(2-thiazolylmethyl)phenyl]acetamide and 1.4 g of methyl iodide in 5 ml of toluene is heated at 140° C. in a closed vessel for 4.5 hours then cooled. Ether is added, the solid collected by centrifugation and then washed several times with ether. The solid is vacuum dried to give 235 mg of the desired product as a tan solid, m.p. 130°-134° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05077409 |
| Source dataset | uspto-grants-1991_12 |
| ORD ID | ord-0dc4ce2c0ec84118bd13303b7ca52038 |
| Source note | uspto-grants-1991_12 |