Sodium Hydroxide → HCID 23672725, compound

HRID 1461960Notes

Reaction equation

HRID 1461960 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:16])=[C:6]([CH:15]=1)[NH:7][C:8](=[O:14])[C:9]([O:11]CC)=[O:10].[OH-].[Na+:18]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:16])=[C:6]([CH:15]=1)[NH:7][C:8](=[O:14])[C:9]([O-:11])=[O:10].[Na+:18]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12803542HCID 12803542, compound

Product 1

HCID 23672725HCID 23672725, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 2 g of ethyl 5-chloro-2-hydroxyoxanilate, 50 ml of ethanol, and 8.2 ml of a 1 normal sodium hydroxide solution was stirred for one hour at 60° C. The reaction mixture was concentrated under reduced pressure and the crystals formed were recovered and dissolved in 100 ml of water. Activated carbon was added to the solution and after filtering the mixture, the filtrate was concentrated under reduced pressure to 10 ml. After adding 10 ml of water to the concentrate, the mixture was allowed to stand overnight and the crystals formed were recovered by filtration to provide 1.1 g of sodium 5-chloro-2-hydroxyoxanilate.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe crystals formed
  3. customwere recovered
  4. dissolutiondissolved in 100 ml of water
  5. additionActivated carbon was added to the solution
  6. filtrationafter filtering the mixture
  7. concentrationthe filtrate was concentrated under reduced pressure to 10 ml
  8. additionAfter adding 10 ml of water to the concentrate
  9. waitto stand overnight
  10. customthe crystals formed
  11. filtrationwere recovered by filtration

Sources & evidence

ORD record
ord-f6760341617a4c58b0384752d701bd17
Source dataset
uspto-grants-1984_07
Patent number
US04457872

Reaction notes

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