Bisphenol A → HCID 13343962, compound

Participants

Reaction Conditions

Reaction Steps

To a 250 ml round bottom flask equipped with a water condenser, drying tube, magnetic stirrer, and addition funnel was added 4,4'-isopropylidenediphenol (4.57 g, 20 mmol), triethylamine (4.24 g, 42 mmol), and acetonitrile (75 ml). The solution was cooled to 10° C. and O-ethyl S-n-propyl phosphorochloridothioate (8.30 g, 41 mmol) in acetonitrile (25 ml) was added dropwise over 15 minutes. The cooling bath was removed and the reaction warmed to 35° C. for 4 hours. The reaction was diluted with ether (500 ml) and washed successively with water (2×50 ml), 1M NaOH (2×50 ml), 1% HCl (2×50 ml), and brine (2×50 ml). The organic solution was dried (MgSO4) and concentrated under reduced pressure to give the desired product as a colorless oil (6.50 g, 10.8 mmol).

Provenance & Evidence