Sulfuric Acid → HCID 20454432, compound

Participants

Reaction Steps

A mixture of 1.4 g. of 2-(6,8-dichloro-11-oxo-11H-pyrido[2,1-b]quinazolin-2-yl)propionic acid methyl ester, 10 ml. of water, and 10 ml. of concentrated sulfuric acid is stirred for 4 hours at 120° (bath temperature). After cooling, the mixture is diluted with 10 ml. of ice water and adjusted with sodium hydroxide solution to a pH of 4-5. After extraction with ethyl acetate, drying, and concentration of the organic phase, 1.1 g. of 2-(6,8-dichloro-11-oxo-11H-pyrido[2,1-b]quinazolin-2-yl)propionic acid is obtained, m.p. 241° (dimethylformamide-water).

Provenance & Evidence