2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester → Ethyl 2-cyano-3-(3-n-butyl-2-pyridylamino)acrylate
Reaction equation
[NH2:1][C:2]1[C:7]([CH2:8][CH2:9][CH2:10][CH3:11])=[CH:6][CH:5]=[CH:4][N:3]=1.C(O[CH:15]=[C:16]([C:22]#[N:23])[C:17]([O:19][CH2:20][CH3:21])=[O:18])C.C(C(=CNC1C=CC(CCCC)=CN=1)C(OCC)=O)#N>>[C:22]([C:16](=[CH:15][NH:1][C:2]1[C:7]([CH2:8][CH2:9][CH2:10][CH3:11])=[CH:6][CH:5]=[CH:4][N:3]=1)[C:17]([O:19][CH2:20][CH3:21])=[O:18])#[N:23]Participants
4
Procedure
The title compound (m.p. 98.5°-99.5°, 84% yield) was prepared from 2-amino-3-n-butylpyridine and ethyl ethoxymethylenecyanoacetate in a manner similar to that described for the preparation of ethyl 2-cyano-3-(5-n-butyl-2-pyridylamino)acrylate in Preparation 3D of U.S. Pat. No. 4,122,274.
Sources & evidence
- ORD record
- ord-91ec998c8f06427dba7499092a648528
- Source dataset
- uspto-grants-1984_07
- Patent number
- US04457932
Reaction notes
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