Ethyl 2-cyano-3-(3-n-butyl-2-pyridylamino)acrylate → HCID 178440997, compound

HRID 1461982Notes

Reaction equation

HRID 1461982 reaction equation
[C:1]([C:3](=[CH:9][NH:10][C:11]1[C:16]([CH2:17][CH2:18][CH2:19][CH3:20])=[CH:15][CH:14]=[CH:13][N:12]=1)[C:4](OCC)=[O:5])#[N:2].[NH:21]1C(C2C(=O)N3C=CC=CC3=NC=2)=N[N:23]=[N:22]1>>[CH2:17]([C:16]1[C:11]2=[N:10][CH:9]=[C:3]([C:1]3[NH:2][N:23]=[N:22][N:21]=3)[C:4](=[O:5])[N:12]2[CH:13]=[CH:14][CH:15]=1)[CH2:18][CH2:19][CH3:20]

Participants

3

Reactant 2

HCID 70514726Ethyl 2-cyano-3-(3-n-butyl-2-pyridylamino)acrylateHCID 178515422HCID 178515422, compound

Product 1

HCID 178440997HCID 178440997, compoundYield 30%

Procedure

The title compound (m.p. 255.5°-257.5° with decomposition, 30% yield) was prepared from ethyl 2-cyano-3-(3-n-butyl-2-pyridylamino)acrylate in a manner similar to that described for the preparation of 3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one in Example 2 of U.S. Pat. No. 4,122,274.

Sources & evidence

ORD record
ord-de54feadfcee4874a2ee940eb7dba517
Source dataset
uspto-grants-1984_07
Patent number
US04457932

Reaction notes

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