Ethyl 2-cyano-3-(3-chloro-2-pyridylamino)acrylate → HCID 178515423, compound

HRID 1461984Notes

Reaction equation

HRID 1461984 reaction equation
[C:1]([C:3](=[CH:9][NH:10][C:11]1[C:16]([Cl:17])=[CH:15][CH:14]=[CH:13][N:12]=1)[C:4](OCC)=[O:5])#[N:2].[NH:18]1C(C2C(=O)N3C=CC=CC3=NC=2)=N[N:20]=[N:19]1>>[Cl:17][C:16]1[C:11]2=[N:10][CH:9]=[C:3]([C:1]3[NH:2][N:20]=[N:19][N:18]=3)[C:4](=[O:5])[N:12]2[CH:13]=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 70515126Ethyl 2-cyano-3-(3-chloro-2-pyridylamino)acrylateHCID 178515422HCID 178515422, compound

Product 1

HCID 178515423HCID 178515423, compoundYield 44%

Procedure

The title compound (m.p. 313°-315° with decomposition, 44% yield) was prepared from ethyl 2-cyano-3-(3-chloro-2-pyridylamino)acrylate in a manner similar to that described for the preparation of 3-(1H-tetrazol-5-yl)4H-pyrido[1,2-a]pyrimidin-4-one in Example 2 of U.S. Pat. No. 4,122,274.

Sources & evidence

ORD record
ord-4ce9d1ff319a4d55bd82b4b40be0db7c
Source dataset
uspto-grants-1984_07
Patent number
US04457932

Reaction notes

Loading…