HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 3,3-Ethylenedioxy-1alpha-methyl-5alpha-androstan-17-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Cornforth reagent | HCID 2724130 | — |
| Reactant | HCID 13020861 | HCID 13020861 | — |
| Catalyst | Chromium | HCID 23976 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3,3-Ethylenedioxy-1alpha-methyl-5alpha-androstan-17-one | HCID 13020863 | 100.6% |
Reaction Steps
35 g of 3,3-ethylenedioxy-1α-methyl-5α-androstan-17β-ol is stirred in 350 ml of dimethylformamide with 70 g of pyridinium dichromate for 17 hours at room temperature. The reaction solution is stirred into ten times the amount of ethyl acetate, then the thus-separated chromium salts are left behind by decanting, and the organic phase is washed with water. After drying and evaporation, 35 g of 3,3-ethylenedioxy-1α-methyl-5α-androstan-17-one is produced, mp 154° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04457925 |
| Source dataset | uspto-grants-1984_07 |
| ORD ID | ord-6106396883db4b77ad5b838f9403283e |
| Source note | uspto-grants-1984_07 |