HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Ethyl (Z)-alpha-(methoxyimino)-2-(tritylamino)thiazol-4-acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (Z)-Ethyl 2-(hydroxyimino)-2-(2-(tritylamino)thiazol-4-yl)acetate | HCID 6410761 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Ethyl (Z)-alpha-(methoxyimino)-2-(tritylamino)thiazol-4-acetate | HCID 6005279 | 100.2% |
Reaction Steps
A mixture of ethyl (Z)-2-hydroxyimino-2-(2-tritylaminothiazol-4-yl)acetate (II) (5.00 g, 10.9 mmoles), CH3I (2.04 mL, 32.8 mmoles) and K2CO3 (4.54 g, 32.8 mmoles) in dry dimethylsulfoxide (DMSO) (100 mL) was stirred at room temperature overnight and then poured into water (250 mL). The precipitate which formed was collected by filtration, washed with water and dried to give the title compound (5.15 g, quantitative yield). M.p. 115° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04457929 |
| Source dataset | uspto-grants-1984_07 |
| ORD ID | ord-24a8def15120407e8189113bc3f853d1 |
| Source note | uspto-grants-1984_07 |