HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine → 1,3-Diethyl-8-[6-hydrazino-3-pyridyl]xanthine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 1,3-Dipropyl-8-(6-chloro-3-pyridyl)xanthine | HCID 10089070 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1,3-Diethyl-8-[6-hydrazino-3-pyridyl]xanthine | HCID 67054386 | — |
Reaction Conditions
| Temperature | 130 °C |
|---|
Reaction Steps
Compound 1 (500 mg, 1.44 mmol) and hydrazine (4 ml) were put in a pressure tube. Ethanol (30 ml) was added. The pressure tube was flushed with argon, sealed and stirred at 100-160° C. for 10-16 h. After cooling, the resulting solid was collected and washed with methanol and ether to give compound 138 (40 mg). The product was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732455B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-447fb00910f748da9ab706af618b83d6 |
| Source note | uspto-grants-2010_06 |