Dimethylamine → HCID 20453894, compound

HRID 1462125Notes

Reaction equation

HRID 1462125 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][CH2:10][C:11]([F:14])([F:13])[F:12])[N:3]=1.[CH3:15][NH:16][CH3:17].O>CC(C)=O>[Cl:8][C:6]1[N:7]=[C:2]([N:16]([CH3:17])[CH3:15])[N:3]=[C:4]([NH:9][CH2:10][C:11]([F:14])([F:13])[F:12])[N:5]=1

Participants

5

Reactant 3

HCID 674DimethylamineHCID 962WaterHCID 14925797HCID 14925797, compound

Product 1

HCID 20453894HCID 20453894, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

14.8 g (0.06 mol) of 2,4-dichloro-6-(2,2,2-trifluoroethylamino)-s-triazine (prepared as described in Example 3) were dissolved in 100 ml of acetone, and 12 ml of an approximately 45% strength aqueous dimethylamine solution were added dropwise at room temperature. The temperature was kept below 30° C. by cooling with water. The reaction product was precipitated by further addition of water. 14 g (=93% of theory) of 2-chloro-4-dimethylamino-6-(2,2,2-trifluoroethylamino)-s-triazine were obtained; melting point 181° to 184° C.

Workup

  1. customwas kept below 30° C.
  2. customThe reaction product was precipitated by further addition of water

Sources & evidence

ORD record
ord-d933367659634cd7bedc3f4498f5efad
Source dataset
uspto-grants-1984_07
Patent number
US04459151

Reaction notes

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