Tetrahydrofuran → HCID 86739520, compound

Participants

Reaction Steps

32.6 g of 4-hydroxy-3-nitrophenylmethylsulfone are suspended in 250 ml of tetrahydrofurane and to this suspension are added 21 ml of triethylamine. With stirring, 15.7 g of cyclopropanecarboxylic acid chloride are added dropwise to the resultant solution. After the weakly exothermic reaction has subsided, stirring is continued for 3 hours at room temperature and the filtrate is concentrated, affording 42 g of a viscous oil which is digested with petroleum ether. Yield: 40.5 g of pale yellow crystalline product with a melting point of 114°-116° C.

Provenance & Evidence