HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dihydroxybenzoic Acid → 2,3-Dihydro-1,4-benzodioxin-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dihydroxybenzoic Acid | HCID 19 | — |
| Reactant | Oxygen | HCID 977 | — |
| Reactant | 1,1-Dibromoethane | HCID 11201 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2,3-Dihydro-1,4-benzodioxin-5-carboxylic acid | HCID 78184 | 96.7% |
Reaction Steps
2,3-Dihydroxybenzoic acid (25 g, 0.16 mol) was heated under reflux in an oxygen-free atmosphere with potassium hydroxide (26.42 g, 0.47 mole) and dibromoethane (13.46 g, 0.07 mol) using 95% ethanol (60 ml) and water (142 ml as solvent as described in J. Org. Chem. (1948), 13, 489-95 to give 2,3-ethylenedioxybenzoic acid (12.2 g, 43%), m.pt. 195°-196° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04459300 |
| Source dataset | uspto-grants-1984_07 |
| ORD ID | ord-611ebd0e598a4984b3023e430c73e3db |
| Source note | uspto-grants-1984_07 |