Acetic Anhydride → HCID 14772171, compound

HRID 1462186Notes

Reaction equation

HRID 1462186 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[N:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[CH3:20])[NH:11][N:10]=2)[CH:6]=[CH:7][CH:8]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22]>>[C:21]([N:11]1[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH3:20])=[N:13][C:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=2)=[N:10]1)(=[O:23])[CH3:22]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 134253s-Triazole, 5-(m-methoxyphenyl)-3-(o-tolyl)-

Product 1

HCID 14772171HCID 14772171, compound

Procedure

A solution of 0.8 g (0.003 mole) of 3-(3-methoxyphenyl)-5-(2-methylphenyl)-1H-1,2,4-triazole and 3 ml (0.00317 mole) of acetic anhydride was heated for two hours on a hot water bath. After evaporating the excess of anhydride by distillation under vacuum, the obtained residue was taken up with a mixture of diisopropyl ether and light petroleum. After standing overnight, a precipitate formed which was recovered by filtration. Yield: 0.72 g (78%) of the title compound M.p. 107°-110° C. Δδ=-0.26.

Workup

  1. customAfter evaporating the excess of anhydride
  2. distillationby distillation under vacuum
  3. additionthe obtained residue was taken up with a mixture of diisopropyl ether and light petroleum
  4. customa precipitate formed which
  5. filtrationwas recovered by filtration

Sources & evidence

ORD record
ord-039fb12b1bfa492db7091e1ebdfbcf70
Source dataset
uspto-grants-1984_07
Patent number
US04459302

Reaction notes

Loading…