Acetic Anhydride → HCID 14772199, compound

HRID 1462191Notes

Reaction equation

HRID 1462191 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[CH3:18])[NH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:19](OC(=O)C)(=[O:21])[CH3:20]>>[C:19]([N:10]1[CH:11]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:8]=[C:9]1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH3:18])(=[O:21])[CH3:20]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 178424201HCID 178424201, compound

Product 1

HCID 14772199HCID 14772199, compound

Procedure

0.702 g (0.003 mole) of the compound of Example 26 and 3 ml (0.00317 mole) of acetic anhydride were heated on an oil bath at 95° C. for 2 hours, then the excess of acetic anhydride was distilled under vacuum. The obtained residue was crystallized from tert-butylmethyl ether/light petroleum. Yield 0.69 g (83%) of the title compound M.p. 102°-4° C.

Workup

  1. distillationthe excess of acetic anhydride was distilled under vacuum
  2. customThe obtained residue was crystallized from tert-butylmethyl ether/light petroleum

Sources & evidence

ORD record
ord-95e2bdd55ff84a42bcfa4d2aa8c1f20b
Source dataset
uspto-grants-1984_07
Patent number
US04459302

Reaction notes

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