2-Amino-4,6-dimethylpyridine → HCID 178426514, compound

HRID 1462192Notes

Reaction equation

HRID 1462192 reaction equation
[O:1]1[CH2:6][C:5](=S)[NH:4][C:3](=[O:8])[NH:2]1.[NH2:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[N:11]=1>>[CH3:16][C:14]1[CH:13]=[C:12]([CH3:17])[N:11]=[C:10]([NH:9][C:5]2[CH2:6][O:1][NH:2][C:3](=[O:8])[N:4]=2)[CH:15]=1

Participants

3

Reactant 2

HCID 215072-Amino-4,6-dimethylpyridineHCID 30069082H-1,2,4-Oxadiazin-3(4H)-one, dihydro-5-thioxo-

Product 1

HCID 178426514HCID 178426514, compoundYield 69%

Procedure

To 0.5 g (0.0043 mole) of 6H-1,2,4-oxadiazin-3(2H)-one-5(4H)-thione dissolved in 10 ml of freshly distilled dry dioxane is added 0.56 g (0.0043 mole) of 2-amino-4,6-dimethyl pyridine. The reaction mixture is stirred at room temperature for 17 hours and the dioxane removed on a rotovap. The crystalline material is washed with chloroform, then with ether to give 0.65 g (69 percent) of 5-((4,6-dimethyl-2-pyridinyl)amino)-6H-1,2,4-oxadiazin-3(2H)-one.

Workup

  1. distillationof freshly distilled dry dioxane
  2. customthe dioxane removed on a rotovap
  3. washThe crystalline material is washed with chloroform

Sources & evidence

ORD record
ord-c4b13f03253943059cef5dc8feb265f2
Source dataset
uspto-grants-1984_07
Patent number
US04459403

Reaction notes

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