Imidazole → HCID 20454106, compound

HRID 1462200Notes

Reaction equation

HRID 1462200 reaction equation
[O:1]1[CH2:6][C:5](=S)[NH:4][C:3](=[O:8])[NH:2]1.[NH:9]1[CH:13]=[CH:12][N:11]=[CH:10]1>O1CCOCC1>[N:9]1([C:5]2[CH2:6][O:1][NH:2][C:3](=[O:8])[N:4]=2)[CH:13]=[CH:12][N:11]=[CH:10]1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 30069082H-1,2,4-Oxadiazin-3(4H)-one, dihydro-5-thioxo-

Product 1

HCID 20454106HCID 20454106, compoundYield 56.2%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 1.0 g (0.0075 mole) of 6H-1,2,4-oxadiazin-3(2H)-one-5(4H)-thione in 50 ml of freshly distilled dry dioxane is added 0.52 g (0.0077 mole) of imidazole. After stirring at room temperature for 17 hours, the solution is filtered, washed with chloroform and dried to give a yield of 0.7 g (56 percent) of 5-(1H-imidazol-1-yl)-6H-1,2,4-oxadiazin-3(2H)-one.

Workup

  1. filtrationthe solution is filtered
  2. washwashed with chloroform
  3. customdried

Sources & evidence

ORD record
ord-9118464c35924632a636580a25c244cc
Source dataset
uspto-grants-1984_07
Patent number
US04459403

Reaction notes

Loading…