Morpholine → HCID 20454114, compound

HRID 1462203Notes

Reaction equation

HRID 1462203 reaction equation
[O:1]1[CH2:6][C:5](=S)[NH:4][C:3](=[O:8])[NH:2]1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>>[N:9]1([C:5]2[CH2:6][O:1][NH:2][C:3](=[O:8])[N:4]=2)[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 30069082H-1,2,4-Oxadiazin-3(4H)-one, dihydro-5-thioxo-

Product 1

HCID 20454114HCID 20454114, compoundYield 74%

Procedure

To a solution of 0.5 g (0.0037 mole) of 6H-1,2,4-oxadiazin-3(2H)-one-5(4H)-thione dissolved in 10 ml of dry freshly distilled dioxane is added 0.34 g (0.0039 mole) of morpholine. After stirring at room temperature for 17 hours, the solution is filtered, washed with chloroform and dried to give a yield of 0.5 g (74 percent) of 5-(4-morpholinyl)-6H-1,2,4-oxadiazin-3(2H)-one.

Workup

  1. dry with materialof dry freshly distilled dioxane
  2. filtrationthe solution is filtered
  3. washwashed with chloroform
  4. customdried

Sources & evidence

ORD record
ord-69bf99f35d254cb9821eb00fe8bf4757
Source dataset
uspto-grants-1984_07
Patent number
US04459403

Reaction notes

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