Aniline → Ethyl 3-anilinobut-2-enoate

Participants

Reaction Steps

Aniline (0.20 mol) and ethylacetoacetate (0.20 mol) are mixed in toluene (200 ml) containing 0.04 g of p-toluenesulfonic acid-hydrate and heated at reflux under a water separator for 1 hour. The toluene is removed under vacuum to afford the ethyl-3-phenylaminobut-2-enoate which can be used as is for the preparation of the 3-quinolinecarboxylic acid, 2-methyl-, ethyl ester.

Provenance & Evidence