反应详情

To 4.99 g (0.039 moles) of 3-oximino-2,4-pentanedione dissolved in acetonitrile (40 ml) was added 4.59 ml (0.039 moles) of methyl 2-aminobutyrate. After stirring for two hours at room temperature, then at reflux for 2.5 h , the reaction mixture was cooled and treated with 15 ml of ethanol and 15 ml of 10% aqueous sodium hydroxide. The resulting mixture was refluxed for 3.8 h, cooled, then extracted with ethyl acetate. The combined organic extracts were dried over anhydrous sodium sulfate, then concentrated in vacuo to give 0.024 moles (62% yield) of 5-acetyl-2-ethyl-4-methylimidazole.

1. temperatureat reflux for 2.5 h
2. temperaturethe reaction mixture was cooled
3. temperatureThe resulting mixture was refluxed for 3.8 h
4. temperaturecooled
5. extractionextracted with ethyl acetate
6. dry with materialThe combined organic extracts were dried over anhydrous sodium sulfate
7. concentrationconcentrated in vacuo