2-(2-Chlorophenyl)acetaldehyde → Trans-6-(2-chlorophenylmethyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one

HRID 1462255Notes

Reaction equation

HRID 1462255 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH:9]=[O:10].ClC1C=C(Cl)[CH:17]=[C:16]([O:21]CC2C=CC=CC=2)[C:13]=1[CH:14]=[O:15]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C@@H:9]1[O:10][C:14](=[O:15])[CH2:13][C@@H:16]([OH:21])[CH2:17]1

Participants

3

Reactant 2

HCID 113786242-(2-Chlorophenyl)acetaldehydeHCID 128028812,4-Dichloro-6-phenylmethoxybenzaldehyde

Product 1

HCID 70432132Trans-6-(2-chlorophenylmethyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one

Procedure

By substituting an equimolar amount of o-chlorophenylacetaldehyde for 2,4-dichloro-6-phenylmethoxybenzaldehyde in step C of Example 1 and following Steps C through F there is obtained a corresponding amount of the title compound.

Sources & evidence

ORD record
ord-57dffd739f224d06bece01256728e82b
Source dataset
uspto-grants-1984_07
Patent number
US04459422

Reaction notes

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