Ethylamine → HCID 13336999, compound

HRID 1462299Notes

Reaction equation

[C:1]([C:3]1[NH:4][C:5](Cl)([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)[C:6](Cl)=[N:7][C:8]=1[C:9]#[N:10])#[N:2].[CH2:20]([NH2:22])[CH3:21]>C1(C)C=CC=CC=1>[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6]([NH:22][CH2:20][CH3:21])=[C:5]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)[N:4]=1)#[N:2]

Participants

Conditions

Temperature: -5 °C

Procedure

2,3-Dicyano-5-chloro-6-chloro-6-(m-fluorophenyl)pyrazine (1.00 g; 0.0039 mole) was dissolved in 30 ml of toluene. The solution was cooled to -5° C., and 0.65 g of a 70% aqueous solution of ethylamine was added dropwise. The mixture was stirred at -5° to 0° C. for 30 minutes. The reaction mixture was worked up in the same way as in Example 13, and recrystallized from ethanol to afford 0.63 g (yield 61%) of 2,3-dicyano-5-ethylamino-6-(m-fluorophenyl)pyrazine.

Workup

customrecrystallized from ethanol

Sources & evidence

ORD record: ord-81a0265575204dfe94e4afcdd2deb7a7
Source dataset: uspto-grants-1984_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04460403

Reaction notes

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