Isopropanol → 2,3-Dicyano-5-chloro-6-isopropoxypyrazine

HRID 1462303Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1462303
[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6](Cl)=[C:5]([Cl:12])[N:4]=1)#[N:2].[CH:13]([OH:16])([CH3:15])[CH3:14]>>[C:9]([C:8]1[C:3]([C:1]#[N:2])=[N:4][C:5]([Cl:12])=[C:6]([O:16][CH:13]([CH3:15])[CH3:14])[N:7]=1)#[N:10]

Komponenten

3

Edukt 2

HCID 3776IsopropanolHCID 6078205,6-Dichloro-2,3-dicyanopyrazine

Produkt 1

HCID 128737522,3-Dicyano-5-chloro-6-isopropoxypyrazineAusbeute 45 %

Versuchsvorschrift

Isopropanol (50 ml) was added to 1.99 g (0.01 mole) of 2,3-dicyano-5,6-dichloropyrazine, and the mixture was refluxed for 10 hours. After the reaction, the isopropanol was distilled off under reduced pressure. The crude product obtained (1.14 g) was chromatographed on a column of silica gel using benzene-n-hexane as an eluent to afford 1.00 g (yield 45%) of 2,3-dicyano-5-chloro-6-isopropoxypyrazine.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 10 hours
  2. customAfter the reaction
  3. distillationthe isopropanol was distilled off under reduced pressure
  4. customThe crude product obtained (1.14 g)
  5. customwas chromatographed on a column of silica gel

Quellen und Nachweise

ORD-Eintrag
ord-4df73b6bddc7400ca2d7c4a93843c1b6
Quelldatensatz
uspto-grants-1984_07
Patentnummer
US04460403

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