反应详情

Isopropanol (50 ml) was added to 1.99 g (0.01 mole) of 2,3-dicyano-5,6-dichloropyrazine, and the mixture was refluxed for 10 hours. After the reaction, the isopropanol was distilled off under reduced pressure. The crude product obtained (1.14 g) was chromatographed on a column of silica gel using benzene-n-hexane as an eluent to afford 1.00 g (yield 45%) of 2,3-dicyano-5-chloro-6-isopropoxypyrazine.

1. temperaturethe mixture was refluxed for 10 hours
2. customAfter the reaction
3. distillationthe isopropanol was distilled off under reduced pressure
4. customThe crude product obtained (1.14 g)
5. customwas chromatographed on a column of silica gel