Acetic Anhydride → HCID 7107477, compound

Participants

Reaction Conditions

Reaction Steps

Ten grams of lithocholic acid was dissolved in 40 ml. of 89.9% formic acid and 8 drops of 70% perchloric acid, and the resulting solution heated to 55° C. with stirring. The solution was then cooled to 40° C. at which time 35 ml. of acetic anhydride was slowly added and the temperature of the reaction mixture maintained between 55°-60° C. The solution was cooled and poured into 500 ml. of water and the resulting precipitate was filtered, washed with water and dried to yield 3α-formyloxy-5β-cholan-24-oic acid.

Provenance & Evidence