反应详情

A solution of 7.2 g of 4-benzyloxy-α-[N-[2-(3-carbamoyl-4-hydroxy-phenoxy)-ethyl]-aminomethyl]-benzyl alcohol in 200 ml of methanol is hydrogenated analogously to Example 7 in the presence of palladium-on-charcoal catalyst (5%). Evaporation of the filtered solution yields crude α-[N-[2-(3-carbamoyl-4-hydroxy-phenoxy)-ethyl]aminomethyl]-4-hydroxybenzyl alcohol, which after recrystallisation from methanol/isopropanol melts at 194°-196°.

1. customEvaporation of the filtered solution