Ammonia → HCID 20452664, compound

Participants

Reaction Steps

After adding about 5 g of Raney nickel catalyst, a solution of 25 g of 2,3-dihydro-2,2-dimethyl-7-(2-oxo-propoxy)-4H-1,3-benzoxazin-4-one in 500 ml of methanol is introduced into an autoclave and ammonia gas is then injected until the pressure is 5 bars. The solution is then hydrogenated at 50° and a hydrogen pressure of 100 bars until the reaction has ceased. After filtering off the catalyst and evaporating the solution, crude 4-(2-amino-propoxy)-salicylamide is obtained, which after recrystallisation from methanol melts at 185°-187°.

Provenance & Evidence